Pediatric low grade focal brainstem glioma: outcomes of different treatment strategies and prognostic factors-Reference-Cited by-同舟云学术

Pediatric low grade focal brainstem glioma: outcomes of different treatment strategies and prognostic factors

Published:2020-10 Issue:30 Volume:16 Page:2401-2410
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Elmaraghi Caroline¹²^ORCID,Bishr Mai K³,Mousa Amr G⁴⁵^ORCID,Ahmed Soha²⁶^ORCID,Refaat Amal⁴⁷,Elhemaly Ahmed⁴⁸^ORCID,Ayadi Moatasem El⁴⁸,Taha Hala⁴⁹,Maher Eslam¹⁰,Elbeltagy Mohamed¹¹¹²,Zaghloul Mohamed S²⁴

Affiliation:

1. Department of Clinical Oncology, Ain Shams University, Cairo, Egypt

2. Department of Radiotherapy, Children’s Cancer Hospital, CCHE 57357, Egypt

3. Department of Clinical Oncology, University College London Hospitals NHS Foundation Trust, London, UK

4. National Cancer Institute, Cairo University, Cairo, Egypt

5. Oncology Center, King Faisal Specialized Hospital & Research Center, Riyadh, Saudi Arabia

6. Department of Clinical Oncology and Nuclear Medicine. Aswan University

7. Department of Radiodiagnosis, Children's Cancer Hospital, CCHE 57357, Egypt

8. Department of Pediatric Oncology, Children's Cancer Hospital, CCHE 57357, Egypt

9. Department of Pathology, Children's Cancer Hospital, CCHE 57357, Egypt

10. Department of Research, Children's Cancer Hospital, CCHE 57357, Egypt

11. Department of Neurosurgery, Children's Cancer Hospital, CCHE 57357, Egypt

12. Faculty of Medicine, Cairo University, Cairo, Egypt

Abstract

Background: This study explores the prognostic factors and outcomes of different treatment modalities in focal brain stem glioma (FBSG). Materials & methods: Pediatric FBSG patients diagnosed during 2010–2017 were retrospectively reviewed for clinical and therapeutic data. Results: A total of 71 cases were identified and the median age was 6.4 years. The 5-year overall- and progression-free survival were 74.5 and 70.6%, respectively. Radiotherapy was the main line of treatment (66.2%) and there were no survival differences between radiotherapy, chemotherapy and surveillance groups. Two independent poor prognostic factors were identified on multivariate analysis: age <8 years and cervicomedullary tumor site (p = 0.02 for both). Conclusion: Surveillance, radiotherapy and chemotherapy have comparable clinical outcomes in pediatric FBSG.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2020-0448

Reference28 articles.

1. Global incidence of malignant brain and other central nervous system tumors by histology, 2003–2007

2. Pediatric Brainstem Gliomas: New Understanding Leads to Potential New Treatments for Two Very Different Tumors

3. A clinicopathologic reappraisal of brain stem tumor classification

4. Surgical approaches for brainstem tumors in pediatric patients

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Childhood brainstem gliomas: A non-aggressive management;Interdisciplinary Neurosurgery;2022-06

2. Cervicomedullary Gliomas in Pediatric Age: A Systematic Review of the Literature and Tertiary Care Center Experience;Pediatric Neurosurgery;2022

3. Pediatric Brainstem Tumors;Pediatric Neurosurgery for Clinicians;2022

4. Very long-term of survival, 5 years and more in diffuse intrinsic pontine brainstem gliomas in children and adolescents treated with Radiotherapy and Nimotuzumab;International Journal of Radiology & Radiation Therapy;2021-06-21

5. Carboplatin/vincristine;Reactions Weekly;2021-02