Different response rates to chemotherapy between Japanese and German esophageal squamous cell carcinoma: patients may be influenced by ERCC1 or ABCB1-Reference-Cited by-同舟云学术

Different response rates to chemotherapy between Japanese and German esophageal squamous cell carcinoma: patients may be influenced by ERCC1 or ABCB1

Published:2020-09 Issue:27 Volume:16 Page:2075-2087
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Narumiya Kosuke¹^ORCID,Bollschweiler Elfriede²,Hölscher Arnulf H²³,Yamamoto Masakazu¹,Drebber Uta⁴,Alakus Hakan⁵,Metzger Ralf⁶,Warnecke-Eberz Ute⁵

Affiliation:

1. Department of Surgery, Institute of Gastroenterology, Tokyo Women’s Medical University, Kawada 8-1, Shinjyuku, Tokyo, 1628666, Japan

2. Medical Faculty, University of Cologne, Kerpener Str. 62, Cologne, 50924, Germany

3. Head Contilia Center for Esophageal Diseases, Elisabeth Hospital, Klara-Kopp-Weg 1, Essen, 45138, Germany

4. Institute of Pathology, University of Cologne, Kerpener Str. 62, Cologne, 50924, Germany

5. Department of General, Visceral & Cancer Surgery, University of Cologne, Kerpner Str. 62, Cologne, 50924, Germany

6. Department of General, Visceral, Thoracic & Cancer Surgery, Caritas Klinikum, Rhine Str. 2, Saarbrücken, 66113, Germany

Abstract

Aim: To find out differences in biomarkers between Japanese and German patients responsible for response after neoadjuvant radio/chemotherapy and survival for esophageal squamous cell carcinoma. Materials & methods: A total of 60 patients from Japan and 127 patients from Germany with esophageal squamous cell carcinoma were analyzed according to three SNPs by real-time PCR. Results: The distribution of the genotypes of ERCC1 rs16115 and ABCB1 C3435T rs1045642 was significantly different between both patients’ groups. Japanese patients had significantly less good response to 5-fluorouracil/cisplatin chemotherapy. The influence of the three SNPs on response varied between patients from Japan and Germany. Conclusion: Different expressions of ERCC1 and ABCB1 SNPs of Japanese patients compared with the German patients partially explain the different response.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2020-0489

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