Utility of circulating tumor cells and DNA in the management of advanced colorectal cancer

Author:

Pan Xiaohong1,Zhang Xiaoli1

Affiliation:

1. Department of Gastrointestinal Surgery, Jingzhou Central Hospital, the Clinical Second Clinical Medical College of Yangtze University, Jingzhou, Hubei, Renmin Road 1, Jingzhou, 434020, PR China

Abstract

Aim: Clinical management of colorectal cancer is challenging. Circulating tumor cells (CTCs) and DNA (ctDNA) are investigated to detect key KRAS mutation and for prognosis for risk stratifications. Materials & methods: 200 advance-stage patients with metastatic disease were selected and followed-up. Serial blood draws were used to quantify CTCs and ctDNA. Results: Both CTCs and ctDNA are strongly associated with colorectal cancer patients. The positive predictive values were 96.5 and 96.3% among CTCs and ctDNA, respectively, for all 200 patients using KRAS mutation. Specificity for healthy controls was 100%. As a prognosis indicator, results demonstrated that patients who had positive CTCs and plasma DNA had worse outcomes. Conclusion: Blood-based assessment of colorectal cancer shows promising results in early-risk stratifications.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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