Real-world evidence of NEPA, netupitant-palonosetron, in chemotherapy-induced nausea and vomiting prevention: effects on quality of life

Author:

Karthaus Meinolf12,Oskay-Özcelik Gülten3,Wülfing Pia4,Hielscher Carsten5,Guth Dagmar6,Zahn Mark-Oliver7,Flahaut Elisa8,Schilling Jörg3

Affiliation:

1. Department of Hematology, Oncology & Palliative Care, Klinikum Neuperlach, Munich, Germany

2. Department of Hematology, Oncology & Palliative Care, Klinikum Harlaching, Munich, Germany

3. Gynecological Oncology Practice, Berlin, Germany

4. Mammazentrum Hamburg am Krankenhaus Jerusalem, Hamburg, Germany

5. Gynecological Oncology Center, Stralsund, Germany

6. Gynecological Oncology Practice, Plauen, Germany

7. Oncology Center Harz, Goslar, Germany

8. Department of Medical Affairs, RIEMSER Pharma GmbH, Berlin, Germany

Abstract

Aim: To determine quality of life, effectiveness and safety of oral netupitant-palonosetron (NEPA)–based antiemetic prophylaxis in the real-world setting. Materials & methods: Prospective, noninterventional study in adults receiving highly or moderately emetogenic chemotherapy and NEPA for three cycles. NEPA was administered per summary of product characteristics. Results: A total of 2429 patients enrolled, 2173 were evaluable. ‘No impact on daily life’ due to vomiting was reported by 84%/82% of patients in the highly emetogenic chemotherapy/moderately emetogenic chemotherapy groups in cycle 1, with rates of 54%/59% for nausea. Overall, complete response rate was 89%/87%/83% in the acute/delayed/overall phases. NEPA was well tolerated. Conclusion: NEPA had beneficial effects on the quality of life of a heterogeneous group of cancer patients and was safe and effective in the real-world setting.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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