Clinicopathological, molecular features and prognosis of colorectal cancer with mucinous component-Reference-Cited by-同舟云学术

Clinicopathological, molecular features and prognosis of colorectal cancer with mucinous component

Published:2021-04 Issue:11 Volume:17 Page:1351-1362
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Li Jianxia¹^ORCID,Yang Liu¹,Bai Fan¹,Cai Yue¹,Zhang Jianwei¹,Wu Zehua¹,Fu Yang¹,Deng Yanhong¹^ORCID

Affiliation:

1. Department of Medical Oncology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China; Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal & Pelvic Floor Diseases, Guangzhou, PR China

Abstract

Background: Colorectal cancer (CRC) with mucinous component is associated with distinct characteristics and controversial prognosis. Patients & methods: A total of 1800 CRC patients were retrospectively enrolled and grouped by the mucinous content of the primary tumors. The clinicopathological characteristics and overall survival rate were compared between groups. Results: Mucinous adenocarcinoma (MAC) and adenocarcinoma with mucinous component (AMC) had higher frequencies of DNA mismatch repair protein deficiency, KRAS, BRAF and PIK3CA mutations as compared to those of conventional adenocarcinoma (CAC). MAC had worse prognosis than CAC. However, MAC was not an independent prognostic factor in multivariable analysis. Conclusion: Molecular features of AMC and MAC were similar, which were different from those of CAC. Neither MAC nor AMC were independent prognostic factors for CRC.

Funder

National Natural Science Foundation of China

Key Technologies Research and Development Program of Guangzhou

Science and Technology Planning Project of Guangdong Province

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2020-1055

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