Relationship of IL-17A and IL-17F genetic variations to cervical cancer risk: a meta-analysis-Reference-Cited by-同舟云学术

Relationship of IL-17A and IL-17F genetic variations to cervical cancer risk: a meta-analysis

Published:2017-05 Issue:5 Volume:11 Page:459-471
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Yang Shujuan¹,Li Chaoying¹,Li Xuejiao²,Huang Xiuling³,Zhao Qingge¹,Liu Danping¹,Wu Siying⁴

Affiliation:

1. Department of Health Related Social & Behavioral Science, West China School of Public Health, Sichuan University, Chengdu, China

2. Chengdu Medical College, Chengdu, China

3. Department of Reproductive Endocrinology, West China Second University Hospital/West China Women's & Children's Hospital, Chengdu, China

4. Fujian Provincial Key Laboratory of Environment Factors & Cancer, School of Public Health, Fujian Medical University, Fuzhou, China

Abstract

Aim: We performed a meta-analysis to determine a more precise relationship of IL-17A and IL-17F polymorphisms with cervical cancer risk. Materials & methods: PubMed, CNKI and Wan Fang databases were searched for studies on these associations using STATA version 10.0 software. Results: Five studies were included. The AG and AA genotypes and A allele of IL-17A rs2275913 were correlated with an elevated risk of cervical cancer. The TT genotype and T allele of IL-17A rs3748067 and the CC genotype and C allele of IL-17F rs763780 carried a moderate risk of cervical cancer, when compared with the wild-type genotype. Conclusion: IL-17A and IL-17F polymorphisms therefore have the potential to act as predictive biomarkers for cervical cancer risk.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2016-0315

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