Association of red cell distribution width with noninfarct-related artery-chronic total occlusion in acute myocardial infarction patients

Abstract

Objective: The presence of chronic total occlusion (CTO) in noninfarct-related artery (non-IRA) is an independent predictor of mortality in acute myocardial infarction (AMI). We investigated whether red cell distribution width (RDW) levels are associated with presence of non-IRA-CTO in AMI (ST-elevation myocardial infarction [STEMI] and non-STEMI). Patients and methods: Patients (n = 858) were categorized into three groups: single vessel disease, multivessel disease (MVD) without CTO and MVD with CTO. Results: MVD with CTO group had higher RDW levels than single vessel disease and MVD without CTO groups (14.87 ± 1.09% vs 13.82 ± 1.01% and 13.87 ± 0.87%, respectively, p < 0.001). In-hospital mortality was also higher in patients with MVD with CTO (p < 0.001). On multivariate analysis, RDW (odds ratio [OR]: 1.761; p < 0.001), age (OR: 1.04; p < 0.001), creatinine (OR: 3.524; p = 0.027), current smoker (OR: 0.489; p = 0.022), hemoglobin (OR: 0.826; p = 0.044), and non-STEMI (OR: 3.065; p < 0.001) were predictors of occurrence of non-IRA-CTO. Conclusion: Increased RDW is independently associated with presence of non-IRA-CTO in AMI patients.