The clinical application of gene editing: ethical and social issues

Author:

Ormond Kelly E1,Bombard Yvonne23,Bonham Vence L4,Hoffman-Andrews Lily5,Howard Heidi67,Isasi Rosario8,Musunuru Kiran9,Riggan Kirsten A10,Michie Marsha11,Allyse Megan12

Affiliation:

1. Department of Genetics & Stanford Center for Biomedical Ethics, Stanford University School of Medicine, Stanford, CA 94305, USA

2. Institute of Health Policy, Management & Evaluation, University of Toronto; Li Ka Shing Knowledge Institute of St Michael’s Hospital, Toronto, ON, Canada

3. Li Ka Shing Knowledge Institute of St Michael’s Hospital, Toronto, ON, Canada

4. Social & Behavioral Research Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA

5. Penn Center for Inherited Cardiac Disease, Penn Medicine, Philadelphia, PA 19104, USA

6. Centre for Research Ethics & Bioethics, Uppsala University, Uppsala, Sweden

7. Society & Ethics Research, Connecting Science, Wellcome Genome Campus, Cambridge, UK

8. Dr J T Macdonald Foundation Department of Human Genetics, Institute of Bioethics & Health Policy, University of Miami Miller School of Medicine, Miami, FL 33136, USA

9. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, PA 19104, USA

10. Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN 55905, USA

11. Department of Bioethics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA

12. Biomedical Ethics Research Program & Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA

Abstract

Gene-editing techniques have progressed rapidly in the past 5 years. There are already ongoing human somatic gene-editing clinical trials for multiple diseases. And there has been one purported scenario of human germline gene editing in late 2018. In this paper, we will review the current state of the technology, discuss the ethical and social issues that surround the various forms of gene editing, as well as review emerging stakeholder data from professionals, the ‘general public’ and individuals and families dealing with genetic diseases potentially treatable by gene editing.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

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