Association of maternal xenobiotic-metabolizing gene polymorphisms with risk of fetal growth restriction

Abstract

Aim: We investigated the association of maternal CYP1A1 MspI, CYP1A1 Ile462Val, GSTT1 null, GSTM1 null and NQO1 Pro187Ser polymorphisms with fetal growth restriction risk. Methods: The polymorphisms were genotyped on 1842 mothers (N = 921 with fetal growth restriction and N = 921 controls). Odds ratios were calculated to estimate the risk. Results: None of the five polymorphisms were associated with risk of fetal growth restriction among never-smoker mothers. However, the variant genotypes of CYP1A1 MspI and GSTM1 null polymorphisms were associated with an increased risk of fetal growth restriction among mothers who were either passive or active smokers. Conclusion: CYP1A1 MspI and GSTM1 null polymorphisms may interact with cigarette smoking to result in an increased risk of fetal growth restriction.