Greener synthesis of ZnO and Ag–ZnO nanoparticles using Silybum marianum for diverse biomedical applications

Author:

Hameed Safia1,Khalil Ali T234,Ali Muhammad1,Numan Muhammad1,Khamlich Saleh34,Shinwari Zabta K25,Maaza Malik24

Affiliation:

1. Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan

2. Department of Eastern Medicine & Surgery, Qarshi University, Lahore, Pakistan

3. UNESCO UNISA Africa Chair in Nanosciences & Nanotechnology, College of Graduate Studies, University of South Africa, Pretoria, South Africa

4. Nanosciences African Network (NANOAFNET), Material Research Department, iThemba LABS, Cape Town, South Africa

5. Pakistan Academy of Sciences, Islamabad, Pakistan

Abstract

Aim: To investigate the physical and biological properties of Silybum marianum inspired ZnO nanoparticles (NPs), Ag–ZnO heterostructures. Experiment: Nanoparticles were characterized using ultraviolet–visible and infrared spectroscopy, x-ray diffraction, high resolution electron microscopy, ζ potential and thermo-gravimetric analysis etc. Results: Ag–ZnO–NPs indicated slightly higher antimicrobial potential then ZnO–NPs. Good antileishmanial (IC50 = 246 μg/ml for Ag–ZnO; 341 μg/ml for ZnO) and antioxidant potential while moderate enzyme inhibition is reported. 2, 2-Diphenyl 1-picrylhydrazyl radical scavenging of Ag–ZnO was higher relative to ZnO–NPs. Nanocosmaceutical formulation of nanoparticles indicated stable antimicrobial performance. Conclusion: Biosynthesized nanoparticles indicated interesting biological properties and should be subjected to further research to establish their pharmacological relevance.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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