Application and mechanism of manganese-coated caramelization nanospheres for active targeting in hepatobiliary tumors-Reference-Cited by-同舟云学术

Application and mechanism of manganese-coated caramelization nanospheres for active targeting in hepatobiliary tumors

Published:2019-11 Issue:22 Volume:14 Page:2973-2985
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Qi Yafei¹,Li Wenqin²,Fang Jiayang³,Xiang Ying¹,Zhu Mingquan⁴,Zhang Xiaoming¹,Ma Xiangxing¹,Wang Qing¹,Zhan Jinhua⁵,Yu Dexin¹

Affiliation:

1. Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, PR China

2. Department of Radiology, Taian Rongjun Hospital of Shandong Province, Taian 271000, PR China

3. Department of Radiology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, 400030, PR China

4. School of Chemistry & Chemical Engineering, Shandong University, Jinan 250100, PR China

5. National Engineering Research Center for Colloidal Materials, Key Laboratory for Colloid & Interface Chemistry of Ministry of Education, Department of Chemistry, Shandong University, Jinan 250100, PR China

Abstract

Aim: To elucidate the MRI mechanisms of manganese oxide-coated carbohydration nanosphere (Mn@CNS) for active targeting in hepatobiliary tumors. Materials & methods: The cytotoxicity, internalization pathway, metabolism and excretion pathway of Mn@CNS were assessed by several cell types. The MRI of Mn@CNS was verified via rat models bearing hepatobiliary tumors. Results: Mn@CNS showed no obvious cytotoxicity. Mice macrophage and hepatocellular Mn content significantly differed between pre- and post-uptake levels (p < 0.01). The animal experiment revealed fine T1 imaging of hepatobiliary tumors with peak enhancement at 3 h. Mn@CNS was metabolized within the cells and excreted mainly via feces. Conclusion: Mn@CNS is safe, biodegradable, and may serve as a new strategy for active target imaging and treatment applications.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2018-0272

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