Bombesin functionalized 64Cu-copper sulfide nanoparticles for targeted imaging of orthotopic prostate cancer-Reference-Cited by-同舟云学术

Bombesin functionalized 64Cu-copper sulfide nanoparticles for targeted imaging of orthotopic prostate cancer

Published:2018-07-01 Issue:14 Volume:13 Page:1695-1705
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Cai Huawei¹²,Xie Fang²³⁴⁵,Mulgaonkar Aditi²,Chen Lihong⁶,Sun Xiankai²⁴,Hsieh Jer-Tsong⁷,Peng Fangyu²³⁴,Tian Rong¹,Li Lin¹,Wu Changqiang⁸⁹,Ai Hua⁹

Affiliation:

1. Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, 610041, PR China

2. Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

3. Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

4. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

5. PET Center, Huashan Hospital, Fudan University, 200040, Shanghai, PR China

6. Department of Biochemistry & Molecular Biology, West China School of Basic Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, PR China

7. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

8. Sichuan Key Laboratory of Medical Imaging & School of Medical Imaging, North Sichuan Medical College, Nanchong, 637000, PR China

9. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, Sichuan, PR China

Abstract

Aim: To synthesize and evaluate the imaging potential of Bom-PEG-[64Cu]CuS nanoparticles (NPs) in orothotopic prostate tumor. Materials & methods: [64Cu]CuS NPs were synthesized in aqueous solution by 64CuCl2 and Na2S reaction. Then PEG linker with or without bombesin peptide were conjugated to the surface of [64Cu]CuS NPs to produce Bom-PEG-[64Cu]CuS and PEG-[64Cu]CuS NPs. These two kinds of NPs were used for testing specific uptake in prostate cancer cells in vitro and imaging of orthotopic prostate tumor in vivo. Results: Bom-PEG-[64Cu]CuS and PEG-[64Cu]CuS NPs were successfully synthesized with core diameter of approximately 5 nm. Radioactive cellular uptake revealed that Bom-PEG-[64Cu]CuS was able to specifically bind to prostate cancer cells, and the microPET-CT imaging indicated clear visualization of orthotopic prostate tumors. Conclusion: Radiolabeled Bom-PEG-[64Cu]CuS NPs have potential as an ideal agent for orthotopic prostate tumor imaging by microPET-CT.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2018-0062

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