Peripheral nerve targeting by procaine-conjugated ribavirin-loaded dual drug nanovesicle

Abstract

Aim: Procaine that is able to reach the peripheral nervous system (PNS) was conjugated as a ligand with lipid nanovesicle and loaded with ribavirin (a broad spectrum antiviral drug incapable of entering the PNS on its own) to target the PNS with a dual-drug effect. Materials & methods: Different physicochemical characterizations, γ-scintigraphy and electromyography of the developed nanovesicle were conducted. Results: Marked capability of the optimized radiolabeled formulation to target PNS was observed in rats. Electromyography signals were reduced after treatment with the formulation on conscious rats. Conclusion: The developed nanocarrier can deliver drug successfully at the PNS and reduce excitation of the nerve and thus give a better therapeutic option for treatment of various diseases and disorders of the PNS.