1. School of Pharmacy, The Faculty of Medical Sciences, King George VI Building, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK
2. Division of Stratified Medicine, Biomarkers & Therapeutics, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
3. Translational Bio-Nanosciences Laboratory & Colorado Center for Nanomedicine & Nanosafety, The Skaggs School of Pharmacy & Pharmaceutical Sciences, Department of Pharmaceutical Sciences, University of Colorado Denver, Anschutz Medical Campus, 1250 East Mountview Blvd, Aurora, CO 80045, USA