Affiliation:
1. Active Carbohydrate Research Institute, Chongqing Key Laboratory of Inorganic Functional Materials, Chongqing Normal University, Chongqing 401331, China
2. School of Chemistry & Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073, China
Abstract
Dextran is a kind of biocompatible, nontoxic and nonimmunogenic biological substance that has been widely used in drug-delivery systems. With further research and understanding of dextran and its derivatives, people can more precisely control the sequence of dextran by chemical and biosynthetic methods as needed, and modify various structures to improve the properties of dextran, such as hydrophilicity, hydrophobicity, temperature sensitivity, pH sensitivity and ionic strength sensitivity, which will further expand the application of dextran and its derivatives in drug-delivery systems. Herein, the application of dextran and its derivatives in gene transfection and drug delivery was summarized and analyzed, and the problems were studied. At the same time, its application prospects are forecasted.
Subject
Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering
Cited by
89 articles.
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