Uptake mechanism of metabolic-targeted gold nanoparticles

Author:

Dreifuss Tamar1,Ben-Gal Tal-Shachar1,Shamalov Katerina2,Weiss Aryeh1,Jacob Avi2,Sadan Tamar1,Motiei Menachem1,Popovtzer Rachela1

Affiliation:

1. Faculty of Engineering & the Institutes of Nanotechnology & Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel

2. The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

Abstract

Aim: To elucidate the interactions, uptake mechanisms and cytotoxicity profile of glucose-functionalized gold nanoparticles (2GF-GNPs), for expanding and advancing the recently proposed technology of metabolic-based cancer detection to a variety of cancer diseases. Methods: Several cell types with different metabolic features were used to assess the involvement of GLUT-1 and different endocytosis pathways in 2GF-GNP uptake, and the cytotoxicity profile of 2GF-GNPs. Results: Cellular uptake of 2GF-GNP strongly correlated with GLUT-1 surface expression, and occurred mainly through clathrin-mediated endocytosis. 2GF-GNPs showed no toxic effect on cell cycle and proliferation. Conclusion: These findings promote development of metabolic-based cancer detection technologies, and suggest that 2GF-GNPs may enable specific cancer detection in a wide range of tumors characterized by high GLUT-1 expression.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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