Effects of silver nanoparticles functionalized with Cornus mas L. extract on architecture and apoptosis in rat testicle-Reference-Cited by-同舟云学术

Effects of silver nanoparticles functionalized with Cornus mas L. extract on architecture and apoptosis in rat testicle

Published:2019-02 Issue:3 Volume:14 Page:275-299
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Opris Razvan¹,Toma Vlad²³⁴,Olteanu Diana¹,Baldea Ioana¹,Baciu Alina Mihaela¹,Lucaci Florica Imre⁵,Berghian-Sevastre Alexandra¹,Tatomir Corina⁶,Moldovan Bianca⁷,Clichici Simona¹,David Luminita⁷,Florea Adrian⁸,Filip Gabriela Adriana¹

Affiliation:

1. Department of Physiology, ‘Iuliu Hatieganu’ University of Medicine & Pharmacy, 1–3 Clinicilor Street, 400006, Cluj-Napoca, Romania

2. Department of Molecular Biology & Biotechnology, Faculty of Biology & Geology, ‘Babes-Bolyai’ University, 5–7 Clinicilor Street, 400006 Cluj-Napoca, Romania

3. Department of Biochemistry & Experimental Biology, Institute of Biological Research, 48 Republicii Street, branch of NIRDBS Bucharest, 400015 Cluj-Napoca, Romania

4. Department of Molecular & Biomolecular Physics, NIRD for Isotopic & Molecular Technologies, 101 Donath Street, 400293 Cluj-Napoca, Romania

5. Physico-Chemical Analysis Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, ‘Babes-Bolyai’ University, 42 Treboniu Laurian Street, 400271 Cluj-Napoca, Romania

6. Departments of Radiobiology & Tumour Biology, ‘Ion Chiricuta’ Oncology Institute, 34-36 Republicii Street, 400015, Cluj-Napoca, Romania

7. Department of Chemistry, Faculty of Chemistry & Chemical Engineering, ‘Babes-Bolyai’ University, 11. Arany Janos, 400028 Cluj-Napoca, Romania

8. Department of Cell & Molecular Biology, ‘Iuliu Hatieganu’ University of Medicine & Pharmacy 6, Louis Pasteur Street, 400349, Cluj Napoca, Romania

Abstract

Aim: To assess ultrastructural changes, alterations in matrix metalloproteinase activity and apoptosis induced by silver nanoparticles (AgNPs) in the rat testicle. Materials & methods: For 45 days, two groups of animals received different doses of AgNPs (0.8 and 1.5 mg/kg b.w.), and a control group was given the buffer used as vehicle for AgNPs. At 7 and 15 days post-treatment, transmission electron microscopy, TUNEL assay, evaluation of NFkB, pNFkB, p53, Bcl-2 and Nrf2 expressions were performed on the removed testes. Results: Transmission electron microscopy revealed severe ultrastructural changes of interstitial tissue and seminiferous epithelium sustained by positive signal for apoptosis. The promatrix metalloproteinase-2 activity and NFkB, Bcl-2 expressions were increased, mainly at 7 days. Conclusion: AgNPs induced severe cell lesions identified even a long time after the exposure.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2018-0193

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