Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2 cancer transformation sensing-Reference-Cited by-同舟云学术

Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2 cancer transformation sensing

Published:2019-07 Issue:14 Volume:14 Page:1791-1804
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Chan Ming-Hsien¹²,Lai Chen-Yu³,Chan Yung-Chieh⁴,Hsiao Michael⁴⁵,Chung Ren-Jei³,Chen Xueyuan²,Liu Ru-Shi¹⁴⁶

Affiliation:

1. Department of Chemistry, National Taiwan University, Taipei 106, Taiwan

2. CAS Key Laboratory of Design & Assembly of Functional Nanostructures, & Fujian Key Laboratory of Nano-materials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, PR China

3. Department of Chemical Engineering & Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan

4. Genomics Research Center, Academia Sinica, Taipei 115, Taiwan

5. Department of Biochemistry College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan

6. Department of Mechanical Engineering & Graduate, Institute of Manufacturing Technology, National Taipei University of Technology, Taipei 106, Taiwan

Abstract

Aim: Matrix metalloproteinase-2 (MMP2) plays an important role in extracellular matrix remodeling, that is, it increases significantly during cancer progression. In this regard, MMP2 monitoring is important. Experiment: A well-designed MMP2-sensitive polypeptide chain was used to link indium phosphide quantum dots (InP QDs) with upconversion nanoparticles (UCNPs) to form a nanocomposite that was utilized as biosensor. Results: We produced a biosensor that can be recognized by MMP2 and determined the presence or absence of MMP2 in cells by identifying difference in fluorescence wavelength. The InP QDs modified the arginylglycylaspartic acid molecules as targeting ligand based on chitosan. Conclusion: The MMP2-based biosensor, named UCNP-p@InP-cRGD, is sensitive and can be applied for biosensing probes.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2018-0524

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