Inhaled chemotherapy adverse effects: mechanisms and protection methods

Author:

Sardeli Chrysanthi1,Zarogoulidis Paul12,Kosmidis Christoforos2,Amaniti Aikaterini3,Katsaounis Athanasios1,Giannakidis Dimitrios1,Koulouris Charilaos1,Hohenforst-Schmidt Wolfgang4,Huang Haidong5,Bai Chong5,Michalopoulos Nikolaos1,Tsakiridis Kosmas6,Romanidis Konstantinos7,Oikonomou Panagoula7,Mponiou Konstantina8,Vagionas Anastasios9,Goganau Alexandru Marian10,Kesisoglou Isaak1,Sapalidis Konstantinos1

Affiliation:

1. Department of Pharmacology & Clinical Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece

2. Third Department of Surgery, ‘AHEPA’ University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece

3. Anesthesiology Department, ‘AHEPA’ University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece

4. Sana Clinic Group Franken, Department of Cardiology/Pulmonology/Intensive Care/Nephrology, ‘Hof’ Clinics, University of Erlangen, Hof, Germany

5. The Diagnostic & Therapeutic Center of Respiratory Diseases, Shanghai East Hospital, Tongji University, Shanghai, China

6. Thoracic Surgery Department, ‘Interbalkan’ European Medical Center, Thessaloniki, Greece

7. Second Department of Surgery, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece

8. Radiotherapy Department, ‘Theageneio’ Anti-Cancer Hospital, Thessaloniki, Greece

9. Oncology Department, General Hospital of Kavala, Kavala, Greece

10. General Surgery Clinic 1, University of Medicine and Pharmacy of Craiova, Craiova County Emergency Hospital, Craiova, Romania

Abstract

Lung cancer is still diagnosed at a late stage due to a lack of symptoms. Although there are novel therapies, many patients are still treated with chemotherapy. In an effort to reduce adverse effects associated with chemotherapy, inhaled administration of platinum analogs has been investigated. Inhaled administration is used as a local route in order to reduce the systemic adverse effects; however, this treatment modality has its own adverse effects. In this mini review, we present drugs that were administered as nebulized droplets or dry powder aerosols for non-small-cell lung cancer. We present the adverse effects and methods to overcome them.

Publisher

Future Medicine Ltd

Subject

Pulmonary and Respiratory Medicine,Oncology

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