Update on HIV integrase inhibitors for the treatment of HIV-1 infection-Reference-Cited by-同舟云学术

Update on HIV integrase inhibitors for the treatment of HIV-1 infection

Published:2019-10 Issue:10 Volume:14 Page:693-709
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Max Blake¹²

Affiliation:

1. Clinical Associate Professor, College of Pharmacy, University of Illinois at Chicago, IL 60612-7229, USA

2. HIV Clinical Pharmacist Ruth M Rothstein CORE Center, Cook County Health & Hospitals System, IL 60612, USA

Abstract

It has been over 30 years since the first antiretroviral agent was approved for treatment of HIV-1 infection and its impact on morbidity and mortality has been dramatic. However, early treatments were hindered by short- and long-term toxicity, poor tolerability, high pill burden, drug interactions and development of drug resistance. A major breakthrough in HIV therapeutics occurred over a decade ago with a new class of drugs that not only are preferred by HIV treatment guidelines but also are changing the HIV treatment paradigm. This new class of drugs are called HIV-1 integrase strand transfer inhibitors and they have established a role in almost every aspect of HIV treatment.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl-2019-0077

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