Distearoyl phosphatidylglycerol and dioleoyl phosphatidylglycerol increase the retention and reduce the toxicity of amphotericin B loaded in nanoemulsions-Reference-Cited by-同舟云学术

Distearoyl phosphatidylglycerol and dioleoyl phosphatidylglycerol increase the retention and reduce the toxicity of amphotericin B loaded in nanoemulsions

Published:2024-01-31 Issue: Volume: Page:
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Marques Borges Gabriel Silva¹²^ORCID,Santos Thais Tunes³^ORCID,Pinto Cristiane Monteiro²^ORCID,Frézard Frédéric³^ORCID,Blanco Verônica Freitas⁴^ORCID,Ondei Roberta⁵^ORCID,Rumbelow Stephen⁴^ORCID,Miranda Ferreira Lucas Antônio²^ORCID,Gontijo de Aguiar Marta Marques²^ORCID,Castro Goulart Gisele Assis²^ORCID

Affiliation:

1. Departamento de Farmácia, Faculdade de Ciências Biológicas e da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, 39100-000, Brazil

2. Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil

3. Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil

4. Croda Inc, Building 2, Suite 200, 777 Scudders Mill Road, Plainsboro, NJ 08540, USA

5. Croda do Brasil, Rua Croda, 580, Campinas, 13054-710, Brazil

Abstract

Aim: To develop nanoemulsions (NEs) loading amphotericin B (AmB) and to evaluate the influence of different excipients on the stability and the supramolecular organization, retention and toxicity of AmB. Materials & methods: The NEs were developed from different oils, surfactants, external media and anionic lipids (disteaoryl phosphatidylglycerol [DSPG] and dioleoyl phosphatidylglycerol [DOPG]). Their impact on the size, pH, zeta potential, AmB encapsulation efficiency, AmB retention and hemolytic potential of the NEs was evaluated. Results & conclusion: The use of soybean oil (lipid matrix), Span 80 (surfactant), phosphate buffer (external phase) and DSPG or DOPG (hydrophobic ion pair) provided better NE stability, higher AmB retention within the NEs and a safer formulation profile in hemolysis tests.

Funder

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Conselho Nacional de Desenvolvimento Científico e Tecnológico

CRODA

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Informa UK Limited

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2023-0256

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