Biogenic synthesis of gold nanoparticles using dual extract of tulsi–Vinca for breast cancer tumor regression in mice

Author:

Pratap Ravi1,Niveria Karishma2,Srivastava Saurabh Kumar1,Chaudhary Shilpi3ORCID,Sharma Poonam4,Verma Anita K25ORCID,Parmar Avanish Singh16ORCID

Affiliation:

1. Department of Physics, Indian Institute of Technology (BHU), Varanasi, 221005, India

2. Nanobiotech Lab Kirori Mal College University of Delhi, Delhi, 110007, India

3. Department of Physics, Punjab Engineering College (Deemed to be University), Chandigarh, 160012, India

4. Department of Dravyagun, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

5. Institution of Eminence Fellow, Delhi School of Public Health, Institution of Eminence, University of Delhi, Delhi, 110007, India

6. Centre for Biomaterials and Tissue Engineering, Indian Institute of Technology (BHU), Varanasi, 221006, India

Abstract

Aim: This work aims to synthesize the gold nanoparticles (GNPs) using a dual extract of tulsi and Vinca (T+V-Gold) for breast cancer tumor regression. Methods: The GNPs were synthesized and characterized for their microscopic, spectroscopic and crystalline properties. Further, the GNPs were investigated for in vitro and in vivo studies for the treatment of the 4T1-induced triple-negative breast cancer murine model. Results: The GNPs for 4T1 tumor-challenged mice resulted in delayed tumor development and lower tumor burden, with T+V-Gold demonstrating the highest prevention of tumor spread. The antitumor effect of T+V-Gold is highly significant in the glutathione family antioxidants glutathione S-transferase and glutathione in tumor tissue samples. Conclusion: The bioefficacy and anticancer outcomes of T+V-Gold nanoformulation can be used as therapeutic agents and drug-delivery vehicles.

Funder

Science and Engineering Research Board

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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