Design of carbon dots for bioimaging and behavior regulation of stem cells

Author:

Li Jing1,Tan Rongshuang1,Bian Xueru1,Ge Zhangjie1,Li Jiamin1,Li Zhihui1,Liao Lingzi1,Yang Ling1,Zhang Rui1,Zhou Ping12ORCID

Affiliation:

1. Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School and Hospital of Stomatology, Lanzhou University, Lanzhou, Gansu Province, 730000, People's Republic of China

2. The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu Province, 730000, People's Republic of China

Abstract

Carbon dots (CDs) have been widely used in bioimaging, biosensing and biotherapy because of their good biocompatibility, optical properties and stability. In this review, we comprehensively summarize the research on CDs in terms of synthesis methods, optical properties and biotoxicity. We describe and envisage the directions for CDs application in stem cell imaging and differentiation, with the aim of stimulating the design of future related CDs. We used ‘carbon dots’, ‘stem cells’, ‘cell imaging’, ‘cell differentiation’ and ‘fate control’ as keywords to search for important articles. The Web of Science database was used to extract vital information from a total of 357 papers, 126 review articles and 231 article proceedings within 12 years (2011–2022).

Funder

China Postdoctoral Science Foundation

The Natural Science Foundation of Gansu Provincial

Fundamental Research Funds for the Central Universities

Lanzhou University Hospital of Stomatology Research Support Fund

The Open Subject Foundation of Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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