Hydroxymethylnitrofurazone lymphatic uptake with nanostructured lipid carrier after oral administration in rats-Reference-Cited by-同舟云学术

Hydroxymethylnitrofurazone lymphatic uptake with nanostructured lipid carrier after oral administration in rats

Published:2024-01-25 Issue: Volume: Page:
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Souza Aline de¹^ORCID,Scarim Cauê Benito²^ORCID,Cotrim Paulo Cesar³^ORCID,Junior Fernando Barbosa⁴^ORCID,Rocha Bruno Alves⁴^ORCID,Calixto Leandro Augusto⁵^ORCID,Correia Cristiano Jesus⁶^ORCID,de Barros Araújo Gabriel Lima¹^ORCID,Löbenberg Raimar⁷^ORCID,Bou-Chacra Nádia Araci¹^ORCID,Breithaupt-Faloppa Ana Cristina⁶^ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, 05508-000, Brazil

2. Department of Drugs & Medicines, School of Pharmaceutical Sciences, São Paulo State University, Araraquara, 14800-901, Brazil

3. Seroepidemiology, Cellular & Molecular Immunology Laboratory, Institute of Tropical Medicine, University of São Paulo, Dr. Enéas de Carvalho Aguiar 470, Jardim América, São Paulo, SP, 05403-000, Brazil

4. Laboratory of Toxicology & Essentiality of Metals, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-903, Brazil

5. Federal University of São Paulo, Department of Pharmaceutical Sciences, Institute of Environmental, Chemical & Pharmaceutical Sciences, Diadema – SP, 09913-030, Brazil

6. Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação (LIM-11), Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo, 01246-903, Brazil

7. University of Alberta, Faculty of Pharmacy & Pharmaceutical Sciences, Edmonton, AB, T6G 2T9, Canada

Abstract

Background: Leishmaniasis, caused by the protozoan Leishmania sp., infects phagocyte cells present in lymphatic organs. This study demonstrates the influence of nanostructured lipid carrier-loaded hydroxymethylnitrofurazone (NLC-NFOH) on lymphatic uptake using a chylomicron-blocking flow model in rats. Method: Lymphatic uptake of NFOH was assessed 1 h after oral administration of dimethyl sulfoxide with NFOH or NLC-NFOH with and without cycloheximide pretreatment. Result: Dimethyl sulfoxide with NFOH and NLC-NFOH showed NFOH serum concentrations of 0.0316 and 0.0291 μg/ml, respectively. After chylomicron blocking, NFOH was not detected. Conclusion: Despite log P below 5, NFOH was successfully taken up by the lymphatic system. Long-chain fatty acids and particle size might be main factors in these findings. NLC-NFOH is a promising and convenient platform for treating leishmaniasis via oral administration.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2023-0263

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