Nanodiamonds-in-oil emulsions elicit potent immune responses for effective vaccination and therapeutics-Reference-Cited by-同舟云学术

Nanodiamonds-in-oil emulsions elicit potent immune responses for effective vaccination and therapeutics

Published:2023-07 Issue:16 Volume:18 Page:1045-1059
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Lin Hsin-Hung¹^ORCID,Wang Chih-Yen¹,Hsieh Feng-Jen¹,Liao Fang-Zhen¹,Su Yu-Kai¹,Pham Minh Dinh²,Lee Chih-Yuan³,Chang Huan-Cheng¹⁴⁵^ORCID,Hsu Hsao-Hsun³⁶^ORCID

Affiliation:

1. Institute of Atomic & Molecular Sciences, Academia Sinica, Taipei 106, Taiwan

2. Institute of Biotechnology, Vietnam Academy of Science & Technology, Ha Noi 100000, Vietnam

3. Department of Surgery, National Taiwan University Hospital & College of Medicine, National Taiwan University, Taipei 100, Taiwan

4. Department of Chemical Engineering, National Taiwan University of Science & Technology, Taipei City 106, Taiwan

5. Department of Chemistry, National Taiwan Normal University, Taipei City 106, Taiwan

6. National Taiwan University Cancer Center, National Taiwan University, Taipei 106, Taiwan

Abstract

Background: The use of nanodiamonds (NDs) and fluorescent nanodiamonds (FNDs) as nonallergenic biocompatible additives in incomplete Freund’s adjuvant (IFA) to elicit immune responses in vivo was investigated. Methods: C57BL/6 mice were immunized with chicken egg ovalbumin (OVA) in IFA and also OVA-conjugated NDs (or OVA-conjugated FNDs) in IFA to produce antibodies. OVA-expressing E.G7 lymphoma cells and OVA-negative EL4 cells were inoculated in mice to induce tumor formation. Results: The new formulation significantly enhanced immune responses and thus disease resistance. It exhibited specific therapeutic activities, effectively inhibiting the growth of E.G7 tumor cells in mice over 35 days. Conclusion: The high biocompatibility and multiple functionalities of NDs/FNDs render them applicable as active and trackable vaccine adjuvants and antitumor agents.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2023-0179

Reference44 articles.

1. The contribution of vaccination to global health: past, present and future

2. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19)

3. Platforms for Production of Protein-Based Vaccines: From Classical to Next-Generation Strategies

4. Vaccine adjuvants: scientific challenges and strategic initiatives

5. Progress in understanding adjuvant immunotoxicity mechanisms

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Nanoparticles for stimulation of neutrophil extracellular trap‐mediated immunity;European Journal of Immunology;2024-01-26