Organ uptake, toxicity and skin clearance of ruthenium contrast agents monitored <i>in vivo</i> by x-ray fluorescence-Reference-Cited by-同舟云学术

Organ uptake, toxicity and skin clearance of ruthenium contrast agents monitored in vivo by x-ray fluorescence

Published:2023-08 Issue:18 Volume:18 Page:1161-1173
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Vogt Carmen¹,Saladino Giovanni M¹^ORCID,Shaker Kian¹^ORCID,Arsenian-Henriksson Marie²^ORCID,Hertz Hans M¹^ORCID,Toprak Muhammet S¹^ORCID,Brodin Bertha A¹^ORCID

Affiliation:

1. Department of Applied Physics, Biomedical & X-Ray Physics, KTH Royal Institute of Technology, SE 10691, Stockholm, Sweden

2. Department of Microbiology Tumor & Cell Biology (MTC), Biomedicum B7, Karolinska Institutet, SE 17165, Stockholm, Sweden

Abstract

Aims: To investigate the distribution and toxicity of ruthenium nanoparticles (Ru NPs) injected intravenously in mice. Methods: We synthesized Ru NPs, followed their biodistribution by x-ray fluorescence (XRF) imaging and evaluated organ toxicity by histopathology and gene expression. Results: Ru NPs accumulated, mainly in liver and spleen, where they were phagocyted by tissue macrophages, giving a transient inflammation and oxidative stress response that declined after 2 weeks. Ru NPs gradually accumulated in the skin, which was confirmed by microscopic examination of skin biopsies. Conclusion: Ru NP toxicity in recipient organs is transient. Particles are at least partially excreted by the skin, supporting a role for the skin as a nanoparticle clearing organ.

Funder

Knut och Alice Wallenbergs Stiftelse

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2023-0061

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