Variants in genes coding for glutathione S-transferases and asthma outcomes in children-Reference-Cited by-同舟云学术

Variants in genes coding for glutathione S-transferases and asthma outcomes in children

Published:2018-06-01 Issue:8 Volume:19 Page:707-713
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Turner Steve¹,Francis Ben²,Wani Nuha¹,Vijverberg Susanne³⁴,Pino-Yanes Maria⁵,Mukhopadhyay Somnath⁶⁷,Tavendale Roger⁷,Palmer Colin⁷,Burchard Esteban G⁸⁹,Merid Simon Kebede¹⁰,Melén Erik¹⁰¹¹,Maitland-van der Zee Anke H³⁴,the Pharmacogenomics in Childhood Asthma Consortium on behalf of

Affiliation:

1. Child Health, University of Aberdeen, UK

2. Department of Biostatistics, University of Liverpool, Liverpool, UK

3. Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

4. Division of Pharmacoepidemiology & Clinical Pharmacology, University of Utrecht, Utrecht, The Netherlands

5. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain

6. Academic Department of Paediatrics, Royal Alexandra Children's Hospital, Brighton & Sussex Medical School, Brighton, UK

7. Population Pharmacogenetics Group, University of Dundee, UK

8. Department of Bioengineering & Therapeutic Sciences & Medicine, University of California, San Francisco, CA, USA

9. Center for Genes, Environment & Health, University of California, San Francisco, CA, USA

10. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

11. Sachs’ Children's Hospital, Södersjukhuset, Stockholm, Sweden

Abstract

Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2018-0027

Reference39 articles.

1. Heterogeneous expression and polymorphic genotype of glutathione S-transferases in human lung.

2. Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution

3. Increased oxidative stress and altered levels of antioxidants in asthma

4. A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma

5. Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Role of Lung Function in Determining Which Children Develop Asthma;The Journal of Allergy and Clinical Immunology: In Practice;2023-03

2. Air pollution associated acute respiratory inflammation and modification by GSTM1 and GSTT1 gene polymorphisms: a panel study of healthy undergraduates;Environmental Health;2023-01-27

3. Molecular monitoring of patient response to painkiller drugs;Expert Review of Molecular Diagnostics;2022-05-04

4. The Pathogenesis of Eosinophilic Asthma: A Positive Feedback Mechanism That Promotes Th2 Immune Response via Filaggrin Deficiency;Frontiers in Immunology;2021-08-13

5. Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility?;Redox Biology;2021-07