Synaptic physiology revised: think zinc!

Abstract

The last few years have seen a dramatic increase in our understanding of the Zn2+ modulatory role in the physiological functioning of the CNS. The availability of new experimental tools, such as the combination of new microscopy techniques with electrophysiological recordings, along with new selective fluorescent probes and chelators has started a revolution in Zn2+ neurobiology. Zn2+ has emerged as a versatile signaling molecule involved in numerous critical neuronal functions spanning from synaptic transmission and plasticity to neuronal differentiation and death.