ERG protein expression as a biomarker of prostate cancer-Reference-Cited by-同舟云学术

ERG protein expression as a biomarker of prostate cancer

Published:2013-12 Issue:6 Volume:7 Page:851-865
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Falzarano Sara Moscovita¹,Magi-Galluzzi Cristina²

Affiliation:

1. R.T. Pathology & Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA

2. R.T. Pathology & Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA.

Abstract

TMPRSS2–ERG is a recurrent rearrangement specific for prostate cancer, leading to the overexpression of a truncated ERG protein product that is amenable to immunohistochemical detection. Two monoclonal anti-ERG antibodies have currently been validated, with comparable sensitivity and specificity for detecting ERG rearrangement. ERG immunostaining has been applied in different settings to elucidate the role of ERG rearrangement and overexpression in prostate cancer tumorigenesis and progression, as well as to investigate potential diagnostic and prognostic applications. In this article we review the literature on the topic and suggest potential future applications.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm.13.105

Reference90 articles.

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2. TMPRSS2-ERG Fusion Prostate Cancer: An Early Molecular Event Associated With Invasion

3. TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer

4. Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome

5. Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer

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