Hepatitis-related renal disease

Abstract

Many glomerular diseases can be caused by viral infections based on the diagnostic criteria, including clinical and laboratory data, and molecular analysis of tissue. Operative pathogenetic mechanisms include kidney tropism of the virus, immune complex formation, direct cytopathogenic effect, and multi-organ failure. Chronic infection with hepatitis virus is etiologically linked to well-defined glomerulopathies. In endemic areas, HBV is associated with both membranous nephropathy and mesangiocapillary glomerulonephritis, while HCV is known to cause cryoglobulinemia-mediated glomerulonephritis and other forms of glomerulonephritis. Renal biopsy with appropriate serological and molecular testing helps to define virus-related glomerular lesions and provides a prognostic and therapeutic guide. Antiviral agents remain the mainstay of treatment.