Development of biomarkers to optimize pediatric patient management: what makes children different?-Reference-Cited by-同舟云学术

Development of biomarkers to optimize pediatric patient management: what makes children different?

Published:2011-12 Issue:6 Volume:5 Page:781-794
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Goldman Jennifer¹,Becker Mara L²³⁴,Jones Bridgette²³⁵,Clements Mark³⁶,Leeder J Steven²³

Affiliation:

1. Children’s Mercy Hospitals & Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA.

2. Division of Clinical Pharmacology & Medical Toxicology, Children’s Mercy Hospitals & Clinics & University of Missouri – Kansas City, Kansas City, MO, USA

3. Department of Pediatrics, Children’s Mercy Hospitals & Clinics & University of Missouri – Kansas City, Kansas City, MO, USA

4. Section of Rheumatology, Children’s Mercy Hospitals & Clinics & University of Missouri – Kansas City, Kansas City, MO, USA

5. Section of Allergy, Asthma & Immunology, Children’s Mercy Hospitals & Clinics & University of Missouri – Kansas City, Kansas City, MO, USA

6. Section of Endocrinology, Children’s Mercy Hospitals & Clinics & University of Missouri – Kansas City, Kansas City, MO, USA

Abstract

Despite the frequent utilization of biomarkers in medical practice, there is a relative paucity of information regarding validated pediatric biomarkers. Frequently, biomarkers found to be efficacious in adults are extrapolated to the pediatric clinical setting without considering that the pathogenesis of many diseases is distinctly different in children, and ontogeny directly influences disease evolution and therapeutic response in children. New and innovative approaches are necessary to provide reliable, validated biomarkers that can be used to improve and advance pediatric medical care.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm.11.96

Reference87 articles.

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5. Neurotoxic Effects and Biomarkers of Lead Exposure: A Review

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