Affiliation:
1. SIGA Technologies, Inc., 4575 SW Research Way, Suite 230, Corvallis, OR 97333, USA
Abstract
Naturally occurring smallpox has been eradicated, yet it remains as one of the highest priority pathogens due to its potential as a biological weapon. The majority of the US population would be vulnerable in a smallpox outbreak. SIGA Technologies, Inc. has responded to the call of the US government to develop and supply to the Strategic National Stockpile a smallpox antiviral to be deployed in the event of a smallpox outbreak. ST-246® (tecovirimat) was initially identified via a high-throughput screen in 2002, and in the ensuing years, our drug-development activities have spanned in vitro analysis, preclinical safety, pharmacokinetics and efficacy testing (all according to the ‘animal rule’). Additionally, SIGA has conducted Phase I and II clinical trials to evaluate the safety, tolerability and pharmacokinetics of ST-246, bringing us to our current late stage of clinical development. This article reviews the need for a smallpox therapeutic and our experience in developing ST-246, and provides perspective on the role of a smallpox antiviral during a smallpox public health emergency.
Reference86 articles.
1. Clinical recognition and management of patients exposed to biological warfare agents
2. The Infectious Dose of Variola (Smallpox) Virus
3. FennerF, Henderson DA, Arita I, Jezek Z, Ladnyi ID:Smallpox and its Eradication. WHO, Switzerland (1988).
4. GellmanB: 4 Nations Thought to Possess Smallpox.The Washington Post, 5 November 2002.
5. US Civilian Smallpox Preparedness and Response Program, 2003
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