Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids-Reference-Cited by-同舟云学术

Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids

Published:2015-12 Issue:12 Volume:10 Page:1953-1968
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Bhargava Nidhi¹,Singh Sukhvinder P²,Sharma Anupam³,Sharma Prince⁴,Capalash Neena¹

Affiliation:

1. Department of Biotechnology, Panjab University, Chandigarh 160014, India

2. NSW Department of Primary Industries, Central Coast Primary Industries Centre, Locked Bag 26, Gosford NSW 2250, Australia

3. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India

4. Department of Microbiology, Panjab University, Chandigarh 160014, India

Abstract

Aim: To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii. Methods & results: Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm formation and production of antioxidant enzymes. Mechanistically, F1 downregulated the expression of autoinducer synthase gene, abaI, and consequently reduced (92%) the production of 3-OH-C12-HSL as determined by ESI–MS. Q-TOF and Q-TRAP analyses suggested the presence of flavonoids viz. licoricone, glycyrin and glyzarin as the active ingredients. Conclusion: This is the first report on quorum quenching activity of G. glabra linked to its flavonoids that downregulated the expression of abaI and attenuated quorum sensing regulated virulence of A. baumannii.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb.15.107

Reference54 articles.

1. Multidrug-resistant acinetobacter infection and their susceptibility patterns in a tertiary care hospital

2. Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models

3. Acinetobacter baumannii and endocarditis, rare complication but important clinical relevance

4. Global spread of drug-resistant Acinetobacter baumannii: molecular epidemiology and management of antimicrobial resistance

5. Isolation and Characterization of an Autoinducer Synthase from Acinetobacter baumannii

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