Exploring the genetic diversity of the 16S rRNA gene of Akkermansia muciniphila in IBD and IBS-Reference-Cited by-同舟云学术

Exploring the genetic diversity of the 16S rRNA gene of Akkermansia muciniphila in IBD and IBS

Published:2019-11 Issue:17 Volume:14 Page:1497-1509
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Presti Alessandra Lo¹^ORCID,Chierico Federica Del²^ORCID,Altomare Annamaria³,Zorzi Francesca⁴,Cella Eleonora⁵,Putignani Lorenza⁶,Luca Guarino Michele Pier³,Monteleone Giovanni⁴,Cicala Michele³,Angeletti Silvia⁷^ORCID,Ciccozzi Massimo⁵

Affiliation:

1. Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy

2. Human Microbiome Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

3. Unit of Digestive Disease, Campus Bio-Medico University, Rome, Italy

4. Gastrointestinal Unit, Department of Systems Medicine, University Tor Vergata, Rome, Italy

5. Unit of Medical Statistics & Molecular Epidemiology, University Campus Bio-Medico, Rome, Italy

6. Unit of Parasitology and Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy

7. Unit of Clinical Laboratory Science, University Campus Bio-Medico, Rome, Italy

Abstract

Aim: The human gastrointestinal tract harbors diverse, abundant microbiota and Akkermansia muciniphila is involved in this community. The aim of this study is to characterize 16 new A. muciniphila 16S ribosomal RNA sequences selected from a metagenomic database from stools of patients with irritable bowel syndrome (IBS), inflammatory bowel diseases and control (CTRLs) subjects by a phylogenetic approach. Materials & methods: A phylogenetic approach was used to study the genetic diversity and SNPs in 16 A. muciniphila 16S ribosomal RNA sequences from stools of 107 individuals, 36 of which were patients affected by IBS, 30 by inflammatory bowel disease and 41 were CTRLs. Results: Phylogenetic analysis confirmed the subdivision into different supported clusters. An increase of variability in IBS has been identified. Conclusion: The genetic variation combined to the relative abundance, contribute to the protective role of A. muciniphila. Phylogenesis represent an additional approach to investigate genetic variability.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2019-0175

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