Rhizopus-host interplay of disseminated mucormycosis in immunocompetent mice-Reference-Cited by-同舟云学术

Rhizopus-host interplay of disseminated mucormycosis in immunocompetent mice

Published:2020-06 Issue:9 Volume:15 Page:739-752
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

dos Santos Amanda R¹^ORCID,Fraga-Silva Thais F²^ORCID,Almeida Débora de F¹,dos Santos Rodolfo F¹,Finato Angela C¹,Amorim Bárbara C¹^ORCID,Andrade Maria I³,Soares Cleverson T³^ORCID,Lara Vanessa S⁴^ORCID,Almeida Nara LM⁴^ORCID,de Arruda Olavo S¹,de Arruda Maria SP¹^ORCID,Venturini James¹⁵^ORCID

Affiliation:

1. Universidade Estadual Paulista (Unesp), Faculdade de Ciências, Bauru, SP, 17033-360, Brazil

2. Universidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatu, SP 18618-689, Brazil

3. Lauro de Souza Lima Institute, Bauru, SP 17034-971, Brazil

4. Universidade de São Paulo (USP), Faculdade de Odontologia de Bauru (FOB), Bauru, SP 17012-901, Brazil

5. Universidade Federal de Mato Grosso do Sul (UFMS), Faculdade de Medicina, Campo Grande, MS 79070-900, Brazil

Abstract

Aim: To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice. Methods: C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra-/- mice were also evaluated. Results: All mouse strains showed an initial spread of R. oryzae in the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra-/- mice succumbed to infection within 16 days. Conclusion: This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2019-0246

Reference49 articles.

1. Zygomycetes in Human Disease

2. Epidemiology and Outcome of Zygomycosis: A Review of 929 Reported Cases

3. Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3)

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