Antifungal activity of 2′-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp.-Reference-Cited by-同舟云学术

Antifungal activity of 2′-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp.

Published:2020-01 Issue:1 Volume:15 Page:21-33
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Medina-Alarcón Kaila P¹^ORCID,L Singulani Junya de¹,Dutra Luiz A²,S Pitangui Nayla de¹,Pereira-da-Silva Marcelo A³⁴,dos Santos Mariana B⁵,Ayusso Gabriela M⁵,Regasini Luis O⁵,Soares Christiane P⁶,Chorilli Marlus⁷,Mendes-Giannini Maria JS¹,Fusco-Almeida Ana M¹

Affiliation:

1. Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara, Proteomics Center, Mycology Laboratory, Araraquara, SP, Brazil

2. Structural Genomics Consortium, Research Institute-UNICAMP, Campinas, SP, Brasil

3. Institute of Physics of Sao Carlos, IFSC/USP, Sao Carlos, SP, Brazil

4. Paulista Central University Center, UNICEP, Sao Carlos, SP, Brazil

5. Universidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Preto, Department of Chemistry and Environmental Sciences, São José do Rio Preto, SP, Brasil

6. Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara, Department of Clinical Analysis, Cytology Laboratory, Araraquara, SP, Brazil

7. Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara, Department of Drugs and Medicines, Araraquara, SP, Brazil

Abstract

Aim: This study aimed to evaluate the activity of 2′-hydroxychalcone-loaded in nanoemulsion (NLS + 2′chalc), the cytotoxic effect and toxicity against Paracoccidioides brasiliensis and Paracoccidioides lutzii using a zebrafish model. Materials & methods: Preparation and physical-chemical characterization of nanoemulsion (NLS) and NLS + 2′chalc were performed. MIC and minimum fungicide concentration, cytotoxicity and toxicity were also evaluated in the Danio rerio model. Results: NLS + 2′chalc showed fungicidal activity against Paracoccidioides spp. without cytotoxicity in MRC5 and HepG2 lines. It also had high selectivity index values and no toxicity in the zebrafish model based on MIC values. Conclusion: NLS + 2′chalc is a potential new alternative treatment for paracoccidioidomycosis.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2019-0095

Reference69 articles.

1. Brazilian guidelines for the clinical management of paracoccidioidomycosis

2. Paracoccidioidomycosis: eco-epidemiology, taxonomy and clinical and therapeutic issues

3. Paracoccidioidomycosis mortality in Brazil (1980-1995)

4. New Trends in Paracoccidioidomycosis Epidemiology

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