HER2 testing and its predictive utility in anti-HER2 breast cancer therapy

Author:

Advani Pooja P1,Crozier Jennifer A1,Perez Edith A12

Affiliation:

1. Division of Hematology & Oncology, Mayo Clinic, 4500 San Pablo Road S., Jacksonville, FL 32224, USA

2. Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road S., Jacksonville, FL 32224, USA

Abstract

Breast cancer treatment is dependent on accurate pathologic diagnosis. HER2 testing is now universally recommended as part of evaluation of invasive breast cancer. HER2 testing is available via various slide and non-slide based assays, and interpretation of results continues to evolve. Herein we review these testing modalities and their incorporation into the 2013 ASCO/CAP guidelines. Once accurate HER2 status has been established the proper treatment based on recent clinical trials can be instituted.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

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