Human mesenchymal stromal cell lysates as a novel strategy to recover liver function-Reference-Cited by-同舟云学术

Human mesenchymal stromal cell lysates as a novel strategy to recover liver function

Published:2015-01 Issue:1 Volume:10 Page:25-38
ISSN:1746-0751
Container-title:Regenerative Medicine
language:en
Short-container-title:Regenerative Medicine

Author:

Herencia Carmen¹,Almadén Yolanda²,Martínez-Moreno Julio M¹,Espejo Isabel³,Herrera Concha⁴,Pérez-Sánchez Carlos¹,Guerrero Fátima¹,Ciria Rubén⁵,Briceño Francisco Javier⁵,Ferrín Gustavo⁵,de la Mata Manuel⁵,Muñoz-Castañeda Juan R¹⁶

Affiliation:

1. Maimónides Institute for Biomedical Research (IMIBIC)/Reina Sofia University Hospital/University of Córdoba, Avda Menendez-Pidal s/n, CP. 14004, Córdoba, Spain

2. Lipid & Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, and CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain

3. Service of Clinical Analysis, Reina Sofía University Hospital, Córdoba, Spain

4. Cellular Therapy Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, Córdoba, Spain

5. Liver Research Unit, CIBERehd, IMIBIC/Reina Sofia University Hospital/University of Córdoba, Córdoba, Spain

6. Vita-Cel, SL. Edificio IMIBIC. Avd. Menendez-Pidal s/n. 14004, Cordoba, Spain

Abstract

Aim: It is unknown if the beneficial effects of mesenchymal stromal cells (MSC) transplantation into the liver are dependent on their anchorage and differentiation into hepatocytes or rather the result of the release of stem cell intracellular content with hepatoprotector properties. Materials & methods: The effects of intact MSC transplantation were compared with the infusion of MSC lysates in an experimental rat model of acute liver failure. Results: A more powerful hepatoprotective and antiapoptotic effect was obtained after infusion of MSC lysates than intact MSC. Changes in IL-6 levels and miRNAs might explain the beneficial effects of MSC lysates. Conclusion: Infusion of MSC lysates show a better hepatoprotective effect than the transplantation of intact MSC.

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/rme.14.59

Reference41 articles.

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