Concomitant use of blinatumomab and donor lymphocyte infusion for mixed-phenotype acute leukemia: a case report with literature review

Author:

Durer Seren1,Durer Ceren1,Shafqat Madeeha1,Comba Isin Yagmur2,Malik Saad1,Faridi Warda1,Aslam Shehroz1,Ijaz Awais1,Tariq Muhammad Junaid1,Fraz Muhammad Asad1,Usman Muhammad1,Khan Ali Y1,McBride Ali3,Anwer Faiz4

Affiliation:

1. Department of Medicine, Division of Hematology, Oncology, Blood & Marrow Transplantation, University of Arizona, Tucson, AZ 85724, USA

2. Department of Medicine, University of Central Florida College of Medicine, Orlando, FL 32827, USA

3. Department of Pharmacy, University of Arizona Cancer Center, Tucson, AZ 85721, USA

4. Department of Hematology, Taussig Cancer Center, Medical Oncology, Cleveland Clinic, Cleveland, OH 44195, USA

Abstract

Blinatumomab and donor lymphocyte infusion (DLI) combination is a promising cancer therapy, whereby blinatumomab might achieve an initial reduction in leukemic-cell burden using T cells, and after tumor clearance, DLI can potentially stimulate the donor immune system to achieve longer lasting remission. Here, we present a 51-year-old female with mixed phenotype acute leukemia who had a hematologic relapse 3 months after she received total body irradiation-based myeloablative allogeneic hematopoietic stem cell transplantation from an unrelated human leukocyte antigen matched (10/10) donor and achieved complete remission with minimal residual disease negativity by multi-parameter flow cytometry using the combination of blinatumomab and DLI. To the best of our knowledge, this is the first report to describe the use of blinatumomab and DLI combination therapy in the treatment of B/myeloid mixed phenotype acute leukemia.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

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