Enteric plexus neuropathy associated with PD-L1 blockade in a patient with small-cell lung cancer

Author:

Trontzas Ioannis P1ORCID,Rapti Vasiliki E1,Syrigos Nikolaos K1,Kounadis George2,Perlepe Nikoleta2,Kotteas Elias A1,Bamias Giorgos2

Affiliation:

1. 3rd Department of Internal Medicine, Oncology Unit, Sotiria General Hospital, Athens School of Medicine, 11527, Greece

2. 3rd Department of Internal Medicine, Gastroenterology Unit, Sotiria General Hospital, Athens School of Medicine, 11527, Greece

Abstract

Immune checkpoint inhibitors have revolutionized the management of patients with cancer. The increasing use of these agents has brought up a new set of adverse events which are widely heterogenous and potentially life-threatening. Rare immune-related adverse events associated with nervous system have not been described thoroughly, but their early recognition and management may be crucial. Immune-related autonomic neuropathy may be presented with a constellation of symptoms ranging from gastrointestinal and urinary complaints, to sweating and hypotension. Intestinal pseudo-obstruction as consequence of immune-related myenteric autonomic neuropathy is an under-recognized, not-well described and potentially fatal adverse event. We herein, present a unique case of enteric plexus neuropathy induced by PD-L1 blockade in a patient with small-cell lung cancer.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Reference16 articles.

1. Autoimmunity, checkpoint inhibitor therapy and immune-related adverse events: A review

2. A review of cancer immunotherapy toxicity

3. National Cancer Institute. Common terminology criteria for adverse events (CTCAE) v5.0 (2017). https://ctep.cancer.gov/protocoldevelopment/electronic_applications/ctc.htm#ctc_50

4. Adverse Effects of Anti-PD-1/PD-L1 Therapy in Non-small Cell Lung Cancer

5. Encephalitis related to immunotherapy for lung cancer: Analysis of a multicenter cohort

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