Contribution of maternal hypertension to autism etiology in a murine model; cerebellar gene expression

Author:

Moussa Hind N1,Sibai Baha M1,Blackwell Sean C1,Leon Mateo G1,Hylin Michael J2,Redell John B2,Liu Yin2,Dash Pramod K2,Longo Monica1

Affiliation:

1. Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, McGovern Medical School at The University of Texas Health Science Center at Houston (UT Health), Houston, TX 77030, USA

2. Neurobiology & Anatomy, McGovern Medical School at The University of Texas Health Science Center at Houston (UT Health), Houston, TX 77030, USA

Abstract

Aim: To study the contribution of maternal hypertension to autism spectrum disorders’ (ASD) phenotype, and gene expression, in a murine model. Materials & methods: To examine the effects of maternal hypertension, we used a well-described transgenic mouse model lacking functional endothelial nitric oxide synthase (eNOS or NOS3). Behavioral testing was performed on male offspring between 8 and 10 weeks of age. Cerebella underwent shotgun transcriptome RNA sequencing. Differentially expressed genes were examined for Gene Ontology enrichment. 2-way-RM-ANOVA, 1-way-ANOVA and Student's t-test were used for statistical analysis. Results & conclusion: Our findings revealed that a deficit in social behavior, the hallmark of ASD, is differentially present in offspring born to hypertensive mothers. Novel ASD-related genes were differentially expressed in the cerebellum, implicating its possible role in ASD etiology. Condensation: Altered uterine environment resulting from maternal hypertension contributes to ASD phenotype, and modifies expression of novel ASD-related genes in cerebella of eNOS heterozygous offspring.

Publisher

Future Medicine Ltd

Subject

Neurology (clinical),Neurology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Lead among children with autism in Iraq. Is it a potential factor?;Annals of Clinical and Analytical Medicine;2019

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