Pregnancy-associated changes in cervical noncoding RNA-Reference-Cited by-同舟云学术

Pregnancy-associated changes in cervical noncoding RNA

Published:2020-06 Issue:12 Volume:12 Page:1013-1025
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Gerson Kristin D¹^ORCID,Haviland Miriam J²,Neo Dayna²,Hecht Jonathan L³⁴,Baccarelli Andrea A⁵,Brennan Kasey JM⁵,Dereix Alexandra E⁵,Ralston Steven J⁶⁷,Hacker Michele R¹⁸⁹,Burris Heather H¹⁰¹¹¹²¹³^ORCID

Affiliation:

1. Department of Obstetrics & Gynecology, Maternal Child Health Research Center, Center for Research on Reproduction & Women's Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA

2. Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA

3. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA

4. Department of Pathology, Harvard Medical School, Boston, MA 02115, USA

5. Department of Environmental Health, Columbia University Mailman School of Public Health, New York, NY 10032, USA

6. Department of Obstetrics & Gynecology, Pennsylvania Hospital, Philadelphia, PA 19107, USA

7. Department of Obstetrics & Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

8. Department Obstetrics, Gynecology & Reproductive Biology, Harvard Medical School, Boston, MA 02115, USA

9. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA

10. Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA

11. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

12. Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA

13. Maternal Child Health Research Center, Center for Research on Reproduction & Women’s Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA

Abstract

Aim: To identify pregnancy-associated changes in cervical noncoding RNA (ncRNA), including miRNA and long noncoding RNA (lncRNA), and their potential effects on biologic processes. Materials & methods: We enrolled 21 pregnant women with term deliveries (≥37 weeks’ gestation) in a prospective cohort and collected cervical swabs before 28 weeks’ gestation. We enrolled 21 nonpregnant controls. We analyzed miRNA, lncRNA and mRNA expression, applying a Bonferroni correction. Results: Five miRNA and three lncRNA were significantly differentially (>twofold change) expressed. Putative miRNA targets are enriched in genes mediating organogenesis, glucocorticoid signaling, cell adhesion and ncRNA machinery. Conclusion: Differential cervical ncRNA expression occurs in the setting of pregnancy. Gene ontology classification reveals biological pathways through which miRNA may play a biologic role in normal pregnancy physiology.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2019-0231

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