A multi-omics approach to investigate the inflammatory response to life course socioeconomic position-Reference-Cited by-同舟云学术

A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

Published:2020-08 Issue:15 Volume:12 Page:1287-1302
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Castagné Raphaële¹^ORCID,Kelly-Irving Michelle¹^ORCID,Krogh Vittorio²^ORCID,Palli Domenico³^ORCID,Panico Salvatore⁴,Sacerdote Carlotta⁵^ORCID,Tumino Rosario⁶^ORCID,Hebels Dennie GAJ⁷^ORCID,Kleinjans Jos CS⁸,de Kok Theo MCM⁸^ORCID,Georgiadis Panagiotis⁹^ORCID,Kyrtopoulos Soterios A⁹^ORCID,Vermeulen Roel¹⁰^ORCID,Stringhini Silvia¹¹^ORCID,Vineis Paolo¹²¹³^ORCID,Chadeau-Hyam Marc¹²^ORCID,Delpierre Cyrille¹^ORCID

Affiliation:

1. LEASP, UMR 1027, Inserm-Université Toulouse III Paul Sabatier, Toulouse, France

2. Epidemiology & Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy

3. Cancer Risk Factors & Lifestyle Epidemiology Unit, Institute for Cancer Research Prevention & Clinical Network-ISPRO, Florence 50141, Italy

4. Department of Clinical Medicine & Surgery, University of Naples Federico II, Naples 80131, Italy

5. Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital & Center for Cancer Prevention (CPO), Turin 10133, Italy

6. Cancer Registry & Department of Histopathology, Provicial Health Authority (ASP) Ragusa 97100, Italy

7. MERLN Institute, Maastricht University, Universiteitssingel 40, 6229ER Maastricht, The Netherlands

8. Department of Toxicogenomics, GROW Institute & Developmental Biology, Maastricht University, Maastricht 6211LK, The Netherlands

9. National Hellenic Research Foundation, Institute of Chemical Biology, Vas. Constantinou 48, 11635 Athens, Greece

10. Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, PO Box 80178, 3508 TD, Utrecht, The Netherlands

11. Institute of Social & Preventive Medicine, Lausanne University Hospital, Lausanne 1010, Switzerland

12. MRC-PHE Centre for Environment & Health, School of Public Health, Department of Epidemiology & Biostatistics, Imperial College London, SW7 2BU, London, UK

13. Molecular & Genetic Epidemiology Unit, Italian Institute for Genomic Medicine (IIGM), Torino 10126, Italy

Abstract

Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2019-0261

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