Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes

Author:

Andersen Emil1ORCID,Altıntaş Ali1,Andersson-Hall Ulrika2,Holmäng Agneta2,Barrès Romain1ORCID

Affiliation:

1. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health & Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. Department of Physiology, Institute of Neuroscience & Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

Abstract

Aim: To investigate the degree by which epigenetic signatures in children from mothers with gestational diabetes mellitus (GDM) are influenced by environmental factors. Methods: We profiled the DNA methylation signature of blood from lean, obese and GDM mothers and their respective newborns. Results: DNA methylation profiles of mothers showed high similarity across groups, while newborns from GDM mothers showed a marked distinct epigenetic profile compared with newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group. Conclusion: Our results suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

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