Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl-Reference-Cited by-同舟云学术

Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl

Published:2020-05 Issue:9 Volume:12 Page:757-770
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Curtis Sarah W¹,Gerkowicz Sabrina A²,Cobb Dawayland O²,Kilaru Varun²,Terrell Metrecia L³,Marder M Elizabeth⁴,Barr Dana Boyd⁴,Marsit Carmen J⁴,Marcus Michele³⁵,Conneely Karen N⁶,Smith Alicia K²⁷

Affiliation:

1. Genetics & Molecular Biology Program, Laney Graduate School, Emory University School of Medicine, 101 Woodruff Circle NE, Ste 4217, Atlanta, GA 30322, USA

2. Department of Gynecology & Obstetrics, Emory University School of Medicine, 101 Woodruff Circle NE, Ste 4217, Atlanta, GA 30322, USA

3. Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA 30322, USA

4. Department of Environmental Health, Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA 30322, USA

5. Department of Pediatrics Emory University School of Medicine, 1518 Clifton Rd, Atlanta, GA 30322, USA

6. Department of Human Genetics, Emory University School of Medicine, 615 Michael St, Atlanta, GA 30322, USA

7. Department of Psychiatry & Behavioral Science, Emory University School of Medicine, 101 Woodruff Circle NE, Ste 4217, Atlanta, GA 30322, USA

Abstract

Aim: Michigan residents were exposed to polybrominated biphenyls (PBBs) when it was accidentally added to the food supply. Highly exposed individuals report sex-specific health problems, but the underlying biological mechanism behind these different health risks is not known. Materials and methods: DNA methylation in blood from 381 women and 277 men with PBB exposure was analyzed with the MethylationEPIC BeadChip. Results: 675 CpGs were associated with PBBs levels in males, while only 17 CpGs were associated in females (false discovery rate <0.05). No CpGs were associated in both sexes. These CpGs were enriched in different functional regions and transcription factor binding sites in each sex. Conclusion: Exposure to PBBs may have sex-specific effects on the epigenome that may underlie sex-specific adverse health outcomes.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2019-0179

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