TCONS_00483150 as a novel diagnostic biomarker of systemic lupus erythematosus-Reference-Cited by-同舟云学术

TCONS_00483150 as a novel diagnostic biomarker of systemic lupus erythematosus

Published:2020-06 Issue:11 Volume:12 Page:973-988
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Guo Gangqiang¹²,Chen Aqiong³,Ye Lele²⁴,Wang Huijing⁵⁶,Chen Zhiyuan²,Yan Kejing²,Shi Xinyu²,Li Baoqing⁷,Lin Qiaoai²,You Xiaohan⁸,Jiang Cizhong¹,Zhang Qingfeng⁹,Ding Xiaokai⁸,Xue Xiangyang²^ORCID,Zhang Huidi⁸

Affiliation:

1. School of Life Sciences and Technology, Tongji University, Shanghai, PR China

2. Department of Microbiology and Immunology, Institute of Molecular Virology and Immunology, Institute of Tropical Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, PR China

3. Department of Rheumatology, Ningbo Medical Center Lihuili Hospital, Ningbo, PR China

4. Department of Gynecologic Oncology, Wenzhou Central Hospital, Wenzhou, PR China

5. Kidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China

6. Department of Rheumatology, South Campus, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China

7. Department of Laboratory Medicine, Second Affiliated Hospital & Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, PR China

8. Department of Nephrology, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, PR China

9. Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, PR China

Abstract

Aim: We aimed to identify differentially expressed Long noncoding RNAs (lncRNAs) and explore their functional roles in systemic lupus erythematosus (SLE). Materials & methods: We identified dysregulated lncRNAs and investigated their prognostic values and potential functions using MiRTarget2, catRAPID omics and Bedtools/blast/Pearson analyses. Results: Among the 143 differentially expressed lncRNAs, TCONS_00483150 could be used to distinguish patients with SLE from healthy controls and those with rheumatoid arthritis and patients with active/stable SLE from healthy controls. TCONS_00483150 was significantly correlated with anti-Rib-P antibody positivity and low C3 levels; TCONS_00483150 dysregulation might contribute to the metabolism of RNA and proteins in SLE patients. Conclusion: Overall, our findings offer a transcriptome-wide overview of aberrantly expressed lncRNAs in patients with SLE and highlight TCONS_00483150 as a potential novel diagnostic biomarker.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2019-0265

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