CpG-methylation-based risk score predicts progression in colorectal cancer-Reference-Cited by-同舟云学术

CpG-methylation-based risk score predicts progression in colorectal cancer

Published:2020-04 Issue:7 Volume:12 Page:605-615
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Deng Yao¹,Wan Hao¹,Tian Jianbo¹,Cheng Xiang²,Rao Meilin¹,Li Jiaoyuan³,Zhang Hongli¹,Zhang Ming¹,Cai Yimin¹,Lu Zequn¹,Li Yue¹,Niu Siyuan¹,Shen Na³,Chang Jiang¹,Fang Zemin⁴,Zhong Rong¹

Affiliation:

1. Department of Epidemiology & Biostatistics & Ministry of Education Key Lab of Environment & Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei 430030, PR China

2. Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022, PR China

3. Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, PR China

4. Division of Cardiothoracic & Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, PR China

Abstract

Aim: To identify patients with colorectal cancer (CRC) who are at a truly higher risk of progression, which is key for individualized approaches to precision therapy. Materials & methods: We developed a predictor associated with progression-free interval (PFI) using The Cancer Genome Atlas CRC methylation data. Results: The risk score was associated with PFI in the whole cohort (p < 0.001). A nomogram consisting of the risk score and other significant clinical features was generated to predict the 3- and 5-year PFI in the whole set (area under the curve: 0.79 and 0.71, respectively). Conclusion: The risk score based on 23 DNA-methylation sites may serve as the basis for improved prediction of progression in patients with CRC in future clinical practice.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2019-0300

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