Torque Teno virus and cancers: current knowledge

Author:

Lasagna Angioletta1ORCID,Piralla Antonio2,Borgetto Sabrina1,Quaccini Mattia1,Baldanti Fausto23,Pedrazzoli Paolo14

Affiliation:

1. Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy

2. Microbiology & Virology Department, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy

3. Dept. of Clinical Surgical Diagnostic & Pediatric Sciences, University of Pavia, Viale Camillo Golgi 19, 27100, Pavia, Italy

4. Dept. of Internal Medicine & Medical Therapy, University of Pavia, Viale Camillo Golgi 19, 27100, Pavia, Italy

Abstract

Aim: The aim of this systematic review is to assess the current knowledge about the relationship between Torque Teno virus (TTV) and cancer in different settings. Methods: A systematic search was conducted in Medline via PubMed, Embase and Cochrane Library from the inception to the end of January 2023. Results: 34 articles were included in the qualitative synthesis of this review and 2145 patients with solid tumors have been analyzed. The most prevalent cancer types were hepatocellular carcinoma (HCC) and lung cancer. Conclusion: TTV has proven its role as a marker of functional immune competence in the setting of hematopoietic stem cell transplantation (HSCT), but in the oncological field is yet to be defined.

Publisher

Future Medicine Ltd

Subject

Virology

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