Potential roles of core and core+1 proteins during the chronic phase of hepatitis C virus infection

Author:

Malekshahi Asra1,Alamdary Ashkan2ORCID,Safarzadeh Ali3ORCID,Khavandegar Armin4ORCID,Nikoo Hadi Razavi56ORCID,Safavi Mahshid4,Ajorloo Mobina4,Bahavar Atefeh6ORCID,Ajorloo Mehdi7ORCID

Affiliation:

1. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran

2. Department of Biology, Science & Research Branch, Islamic Azad University, Tehran, Iran

3. Department of Biology, University of Padova, Padova, Italy

4. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran

5. Infectious Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran

6. Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

7. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran

Abstract

The HCV Core protein is a multifunctional protein that interacts with many viral and cellular proteins. In addition to the encapsidation of the viral genome, it can disturb various cellular pathways and impede antiviral cellular responses such as interferon (IFN) production. The Core protein can also disrupt the functions of immune cells against HCV. The Core protein helps viral infection persistency by interfering with apoptosis. The Core+1 protein plays a significant role in inducing chronic HCV infection through diverse mechanisms. We review some of the mechanisms by which Core and Core+1 proteins facilitate HCV infection to chronic infection. These proteins could be considered for designing more sufficient treatments and effective vaccines against HCV.

Publisher

Future Medicine Ltd

Subject

Virology

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