Affiliation:
1. Jefferson Institute of Molecular Medicine, Thomas Jefferson University, 233 S. 10th Street, Room 509 BLSB, Philadelphia, PA 19107-15541, USA.
Abstract
Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiology characterized by pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often progressive fibrotic process. Numerous biomarkers reflecting the three main pathogenetic mechanisms in systemic sclerosis have been described; however, aside from several disease-specific autoantibodies, other biomarkers have not been thoroughly validated and require further study. Thus, there is an unmet need for validated biomarkers for diagnosis, disease classification, and evaluation of organ involvement and therapeutic response in systemic sclerosis.
Subject
Biochemistry (medical),Clinical Biochemistry,Drug Discovery
Reference124 articles.
1. Scleroderma
2. BolsterMB, Silver RM: Clinical features of systemic sclerosis. In:Rheumatology. Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH (Eds). Mosby Elsevier, Philadelphia, PA, USA1375–1385 (2008).
3. Systemic sclerosis: a prototypic multisystem fibrotic disorder
4. Natural history of systemic sclerosis and the assessment of disease activity, severity, functional status, and psychologic well-being
Cited by
66 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献